Small volume parenteral (SVP) solutions are typically 20 ml or less in volume and are packaged according to the intended use.
Ampoules, bottles, bags, and pre-filled syringes are the most common packaging types for SVP. SVP also can be Lyophilized powder. Most SVPs are not thermally stable and therefore require sterile filling.
Sterilization filtration is usually used after synthesis or before filling. If sterilization filtration can be used at both locations, a double guarantee of sterilization could be acquired.
To avoid premature clogging of the final filtration, pre-filtration can be used to reduce the bioburden and particle content.
