Human plasma contains a large number of therapeutically valuable proteins such as albumin, various immunoglobulins, factor VIII, fibronectin, and other proteins. The process of extracting and purifying these proteins is known as plasma isolation.
Plasma separation is achieved through a series of extraction and precipitation steps. Impurities in the plasma, which can cause product instability and clogging of downstream filters, must be removed using pre-filters.
The solution is also clarified and impurities removed prior to chromatography and ultrafiltration. For the decontamination of heat-sensitive proteins, final decontamination filtration is usually used.
